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The body needs plenty of rest and needs to stay hydrated during the illness. Alcohol can impair the immune system from fighting off infections and cause similar side effects as antibiotics, such as:. Cephalexin and multivitamin with minerals should not be taken orally at the same time. David Hardin answered Wound care 37 years experience. Summary of Alcohol and Keflex So, does alcohol affect Keflex? You should take multivitamin with minerals at least three hours after taking cephalexin While it is safe to consume alcohol in moderation while taking cephalexin, the two substances can cause similar side effects. Using Alcohol While On Keflex (cephalexin) Excessive alcohol use can lead to liver damage and lowered immune function. First, with alcohol and Keflex you may experience worse side effects of the medicine or the alcohol than you would if you had either alone, such as nausea or headache Yes: You can drink alcohol while taking Keflex but do it in moderation at most. Products that contain zinc may interfere with the absorption of cephalexin into the bloodstream and reduce its effectiveness. +0 FM Fmhjb 10 Feb 2018 Agreed DE Delila 28 Sep 2014 Agreed, it's not a good idea, it can affect its efficacy +0 FM Fmhjb 10 Feb 2018 Doesn't effect efficiency but can intensify side effects BA balbanese 28 Sep 2014 Not advisable, it can prohibit its beneficial attributes. Is it dangerous to drink alcohol while taking cephalexin? Michael Ein answered Infectious Disease 49 years experience Yes: You can drink alcohol while taking keflex / cephalexin but do it in moderation at most. There is no interaction between alcohol and cephalexin. If you have a significant infection it would be best to abstain until its better However, some of the more common side effects of this drug are similar to some of the more bothersome effects of alcohol, such as dizziness, drowsiness, and nausea. +0 keflex, alcohol Further information Keflex uses and safety info. It doesn’t necessarily directly affect Keflex, but that doesn’t mean you should drink while on this antibiotic. 2k views Answered >2 years ago Merged Thank 4 thanks Dr. If you have a significant infection it would be best to abstain until its better. There is no drug interaction between cephalexin (Keflex) and alcohol, but it is not recommended to drink alcohol when recovering from an illness. 1 doctor answer • 1 doctor weighed in Dr. Taking them in combination may make these side effects worse.